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Singapore-Cambridge A-Level Biology (H2)

A-Level · SEABBiology50 notes in 6 folders, 293 KB

Notes for Singapore-Cambridge A-Level Biology (H2, 9477), in folders for the syllabus's four core ideas and two extension topics in its order, with the practical investigations in the topics they belong to. Each folder holds one note per sub-topic or group of small ones, following the syllabus for examinations from 2027. Delete the folders your course leaves out once the notes are yours.

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  • The cell and biomolecules of life
    • Cell structure and the cell theory6 KB
    • Microscopy and measuring cells5 KB
    • Bacterial cells and viruses4 KB
    • Carbohydrates and lipids7 KB
    • Proteins7 KB
    • Cell membranes and transport7 KB
    • Enzymes9 KB
    • Stem cells4 KB
  • Genetics and inheritance
    • DNA and RNA5 KB
    • DNA replication5 KB
    • Transcription and translation6 KB
    • Genome organisation and non-coding DNA5 KB
    • Viral genetics7 KB
    • Bacterial genetics5 KB
    • Control of gene expression6 KB
    • DNA analysis techniques6 KB
    • Mutations and chromosomal aberrations7 KB
    • The mitotic cell cycle5 KB
    • The molecular biology of cancer6 KB
    • Meiosis5 KB
    • Genetic terms and inheritance8 KB
    • Linkage, crossing over and epistasis6 KB
    • Genotype, environment and variation5 KB
    • The chi-squared test5 KB
  • Energy and equilibrium
    • Energy, ATP and the organelles of energy transfer6 KB
    • Photosynthesis, the light-dependent reactions7 KB
    • Photosynthesis, the Calvin cycle4 KB
    • Limiting factors in photosynthesis6 KB
    • Glycolysis, the link reaction and the Krebs cycle6 KB
    • Oxidative phosphorylation and chemiosmosis5 KB
    • Anaerobic respiration and the rate of respiration6 KB
    • Cell signalling6 KB
    • Blood glucose regulation6 KB
  • Biological evolution
    • Variation and natural selection6 KB
    • Evidence for evolution7 KB
    • Species and speciation6 KB
    • Classification and phylogeny6 KB
    • The Hardy-Weinberg model5 KB
    • Standard deviation and the t-test5 KB
  • Infectious diseases
    • Innate and adaptive immunity5 KB
    • Lymphocytes and the immune response6 KB
    • Antibodies and antibody diversity7 KB
    • Vaccination6 KB
    • Viral infections: influenza and HIV6 KB
    • Bacterial infection and antibiotics6 KB
    • Epidemiology: outbreaks and the basic reproduction number5 KB
  • Impact of climate change on animals and plants
    • Causes of climate change and carbon footprints6 KB
    • Effects of climate change on the environment and mangroves6 KB
    • Food supply, habitats and biodiversity6 KB
    • Insects, temperature and mosquito-borne disease6 KB

The first note

The cell and biomolecules of life / Cell structure and the cell theory

## The cell theory The **cell theory** has three parts. Living organisms are composed of cells, the cell is the smallest unit of life, and all cells come from pre-existing cells. The second part means that nothing smaller than a cell carries out all the processes of life (metabolism, growth, response to the environment and reproduction) by itself. The third part rules out cells arising from non-living matter under present conditions, and is the reason every cell in a body can be traced back to a single fertilised egg through repeated division. ## Eukaryotic cells and their compartments A eukaryotic cell has a nucleus and a set of membrane-bound compartments. Membranes divide the cell into regions, so enzymes and substrates for one process can be kept together at high concentration and incompatible reactions (for example the breakdown of proteins by lysosomal enzymes) are kept away from the rest of the cytoplasm. Membrane systems also give a large surface area on which enzymes and carriers can be arranged in order. The **cytoplasm** is everything inside the cell surface membrane except the nucleus. Its fluid part, the **cytosol**, is a solution of ions, sugars, amino acids and proteins in which many metabolic reactions, including glycolysis, take place. ### Structures and their functions | Structure | Structure seen in drawings and micrographs | Function | |---|---|---| | Cell surface membrane | Thin phospholipid bilayer around the cell, about 7 nm thick | Controls what…

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