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SQA Advanced Higher Biology

Advanced Higher · SQABiology39 notes in 3 folders, 219 KB

Notes for SQA Advanced Higher Biology (course code C807 77), in folders for the course's three key-area units in their order (Cells and proteins, Organisms and evolution, Investigative biology), with one note per sub-topic or small group of sub-topics. Processes are set out in the order they happen, comparisons are in tables and the laboratory and field techniques are given as method and principle. Follows the course specification valid from session 2026-27 (version 5.0).

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What is inside

  • Cells and proteins
    • Health and safety, dilutions and standard curves5 KB
    • Buffers, colorimetry and centrifugation5 KB
    • Chromatography and electrophoresis6 KB
    • Isoelectric points and separating proteins4 KB
    • Antibodies, immunoassays and microscopy8 KB
    • Aseptic technique and cell culture7 KB
    • The proteome4 KB
    • Intracellular membranes, protein synthesis and the secretory pathway9 KB
    • Amino acids and protein structure6 KB
    • Ligand binding, allostery and phosphorylation10 KB
    • Membrane proteins and transport across membranes5 KB
    • Ion pumps and the sodium-potassium pump5 KB
    • Cell signalling6 KB
    • Nerve impulses and vision9 KB
    • The cytoskeleton and the cell cycle4 KB
    • Control of the cell cycle and apoptosis6 KB
  • Organisms and evolution
    • Fieldwork safety and sampling wild organisms5 KB
    • Identification, taxonomy and model organisms5 KB
    • Monitoring populations and measuring behaviour6 KB
    • Natural selection, sexual selection and genetic drift6 KB
    • The Hardy-Weinberg principle and fitness6 KB
    • Co-evolution, symbiosis and the Red Queen hypothesis4 KB
    • Sexual and asexual reproduction6 KB
    • Meiosis5 KB
    • Sex determination5 KB
    • Parental investment, r and K selection and fertilisation5 KB
    • Mating systems and sexual selection in animals5 KB
    • Niche and the parasite niche4 KB
    • Parasite life cycles and viruses8 KB
    • Transmission and virulence4 KB
    • Defence against parasitic attack5 KB
    • Immune evasion4 KB
    • Treatment and control of parasites5 KB
  • Investigative biology
    • Scientific principles and process5 KB
    • Scientific ethics4 KB
    • Experimental design7 KB
    • Sampling and reliability5 KB
    • Presenting and analysing data6 KB
    • Reporting and evaluating research6 KB

The first note

Cells and proteins / Health and safety, dilutions and standard curves

## Hazard and risk in the laboratory A **hazard** is anything that could cause harm, and **risk** is the likelihood that harm will actually arise from exposure to that hazard. A bottle of concentrated acid is a hazard whether or not anyone touches it; the risk depends on how much is used, how it is handled and who is nearby. The distinction matters because a risk assessment does not try to remove hazards from a laboratory, which is impossible in biology. It identifies each hazard, judges how likely and how serious the harm would be, and then decides on control measures that reduce the risk. The hazards in a biology laboratory fall into a few groups. | Source of hazard | Examples | |---|---| | Substances | toxic or corrosive chemicals, flammable liquids, stains and solvents | | Heat | Bunsen burners, hot plates, water baths, autoclaves | | Organisms | pathogenic bacteria, fungi, and cultures that may contain contaminants | | Equipment | centrifuges, sharp instruments, glassware, electrical equipment such as electrophoresis tanks | Control measures are matched to the hazard. They include handling techniques that keep a substance away from skin and eyes, protective clothing and equipment such as gloves, lab coats and eye protection, working in a fume cupboard for volatile chemicals, balancing a centrifuge so that it cannot fly apart, and **aseptic technique** for organisms, which keeps cultures from escaping into the room as well as keeping contaminants out of the culture. A…

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